Beilstein J. Org. Chem.2011,7, 543–552, doi:10.3762/bjoc.7.62
& Applied Chemistry, Hanyang University, Ansan-si, Gyeonggi-do, 426-791, Korea 10.3762/bjoc.7.62 Abstract The specific rates of solvolysis of isobutyl chloroformate (1) are reported at 40.0 °C and those for isobutylchlorothioformate (2) are reported at 25.0 °C, in a variety of pure and binary aqueous
conformation where the halogen atom is in a trans position with respect to the alkyl group. In Figure 1, the molecular structures for syn-isobutyl chloroformate (1), syn-isobutylchlorothioformate (2), phenyl chloroformate (3), phenyl chlorodithioformate (4), and isopropyl chloroformate (5), and their
a stepwise mechanism via a zwitterionic tetrahedral intermediate [60][61][62][63][64][65].
Isobutyl chloroformate (1) and isobutylchlorothioformate (2) have found use as specific precursors in novel synthetic routes for the preparation of peptidyl carbamate and thiocarbamate inhibitors of the